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"Prohibition will work great injury to the cause of temperance. It is a species of intemperance within itself, for it goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation, and makes a crime out of things that are not crimes. A Prohibition law strikes a blow at the very principles upon which our government was founded."

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Cannabis & Health

Tardive Dyskinesia victims benfit from cannabis

So often the wonder drugs of modern medicine can have side effects that are way worse than the condition they were meant to treat. Information in this article relates to the condition tardive dyskinesia, a movement disorder caused by ingesting the medication Reglan. There are reports that cannabis can have a positive effect on the symptoms of this unfortunate man-made condition.

GENERIC NAME: metoclopramide

BRAND NAME: metoclopramide, Reglan, Reglan ODT, Metozol ODT, Octamide, (Maxolon discontinued)

Metoclopramide is used on a short term basis (4 to 12 weeks) for treating patients with heartburn and esophagitis due to GERD and for treating patients who have gastroparesis. Metoclopramide is used to promote emptying of the stomach prior to radiological examinations and to facilitate passage of tubes passed through the nose or mouth and into the small intestine. It is used for treating impaired function of muscles of the small intestine that may give rise to symptoms that mimic intestinal obstruction (nausea, vomiting, and abdominal distention). Metoclopramide also is used in the treatment of nausea due to surgery or cancer chemotherapy. 

Metoclopramide is a "prokinetic" drug that stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine by interacting with receptors for acetylcholine and dopamine on gastrointestinal muscles and nerves. 

 In some patients, particularly those with diabetes, damage to nerves in the stomach can interfere with function of the muscles and cause delayed emptying of the stomach, resulting in nausea, vomiting, a sense of abdominal fullness and distention, and heartburn (diabetic gastroparesis). Metoclopramide is can be effective in relieving the symptoms related to diabetic gastroparesis by stimulating more rapid emptying of the stomach as well as decreasing the reflux of stomach acid into the esophagus. Dopamine receptors on nerves in the brain are important in producing nausea. Metoclopramide interacts with the dopamine receptors in the brain and can be effective in treating nausea. The FDA approved metoclopramide in June 1985.

The most serious neurological side effects of metoclopramide are symptoms mimicking Parkinson's disease, involuntary muscle movements, facial grimacing, and dystonic reactions resembling tetanus. Fortunately, these more serious side effects are infrequent and usually - though not always - disappear when metoclopramide is discontinued. Patients with Parkinson's disease can experience worsening of symptoms with metoclopramide. Metoclopramide may impair the mental and/or physical abilities to drive or operate machinery. 

The following testimonial provided by

Ben Leer
Benjamin Leer
800-584-6601
National Awareness Coordinator
Tardive Dyskinesia Center

<This email address is being protected from spambots. You need JavaScript enabled to view it.>

Tardive Dyskinesia (TD) is a result of damage to the bodily systems that process dopamine, and is typically caused by exposure to certain neurological medications - including Reglan.

The symptoms of TD, which are irreversible and incurable, mimic those of Parkinson’s disease. Tardive Dyskinesia victims suffer from involuntary, repetitive movements which often continue after the drug is no longer used. some patients do report that their use of marijuana relieves their symptoms. We feature the most up-to-date information on TD, its causes and all known treatment options. Additionally, we distribute free support books and informational packets to our users.

The best treatment is prevention - be very careful with any suggestion of exposure to the drug Reglan or it's competitors;

"...right now we are in the midst of a public outreach, attempting to educate families on the dangers of Reglan. Some studies have shown cannabis to be useful in helping patients manage the symptoms of tardive dyskinesia."